Bile secretion depends on the function of membrane transport systems in hepatocytes and cholangiocytes and on K14341, solute carrier family 10 ( sodium/bile acid cotransporter), member 1 K11822, bile-salt sulfotransferase [ EC:2.8.
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The importance of membrane voltage in uptake of bile salts into hepatocytes is not known. Electrogenicity of the primary bile salt transport process, Na-bile salt cotransport, has been difficult to determine because the large K and Cl conductances of the sinusoidal membrane (GK and GCl, respectively) obscure any transport associated currents. 2003-07-08 Bile salts are the major organic solutes in bile and undergo extensive enterohepatic circulation. Hepatocellular bile salt uptake is mediated predominantly by the Na(+)-taurocholate cotransport proteins Ntcp (rodents) and NTCP (humans) and by the Na(+)-independent organic anion-transporting polypept …. Bile salts are the major organic solutes in It has been proposed that the hepatocellular Na (+)-dependent bile salt uptake system exhibits a broad substrate specificity in intact hepatocytes.
In man, two well-characterized members and three orphan transporters are known. The Na+/taurocholate cotransporting polypeptide (NTCP; SLC10A1) and the apical sodium-dependent bile salt transporter (ASBT; SLC10A2) are critical components of the enterohepatic circulation of bile salts. 1987-03-30 · These results suggest that the proteins involved in Na+/bile salt cotransport are similar in renal and ileal brush-border membranes, but differ from those in hepatocytes. u 1987 Academic Press, Inc. Bile salts are reabsorbed in proximal tubules of rat kidney against a concentration gradient by a Na+-dependent transport system (1). The pre-S1 domain of the large HBsAg protein promotes attachment and entry of HBV into the hepatocyte via liver cell–specific receptor recently identified as Na (sodium) taurocholate cotransporting polypeptide (NTCP), which is an integral membrane protein used in bile acid transport.
The SLC10 family of sodium/bile salt cotransporters contains over 50 members in animal, plant and bacterial species.
Functional Expression Cloning and Characterization of the Hepatocyte Na^+/Bile Acid Cotransport System
These findings identify stomatin as an interactor of NTCP and show that the interaction modulates bile salt transport. petromyzonol sulfate (its endogenous bile salt) with high affinity, but taurocholate with low affinity. The multi-tissue expression pattern suggests that lamprey Slc10a1 can transport other substrates in addition to bile salt. The Na+-taurocholate cotransporting polypeptide (NTCP, SLC10A1) is a liver specific bile salt transporter 1991-12-01 · Burckhardt G, Kramer W, Kurz G, Wilson FA. Photoaffinity labeling studies of the rat renal sodium bile salt cotransport system.
2002-01-01
The Na + /taurocholate cotransporting polypeptide (NTCP; SLC10A1) and the apical sodium-dependent bile salt transporter (ASBT; SLC10A2) are critical components of the enterohepatic circulation of bile salts. NTCP and ASBT are cotransporters that mediate sodium-dependent, electrogenic uptake of mainly bile salts into hepatocytes (NTCP), biliary epithelial cells, ileal enterocytes and renal proximal tubular cells (ASBT). NTCP and ASBT are cotransporters that mediate sodium-dependent, electrogenic uptake of mainly bile salts into hepatocytes (NTCP), biliary epithelial cells, ileal enterocytes and renal proximal The importance of membrane voltage in uptake of bile salts into hepatocytes is not known. Electrogenicity of the primary bile salt transport process, Na-bile salt cotransport, has been difficult to determine because the large K and Cl conductances of the sinusoidal membrane (GK and GCl, respectively) obscure any transport associated currents. The SLC10 family of sodium/bile salt cotransporters contains over 50 members in animal, plant and bacterial species. In man, two well-characterized members and three orphan transporters are known. The importance of membrane voltage in uptake of bile salts into hepatocytes is not known.
It has an important physiological function as the first step in bile acid (BA) reabsorption from the intestine, playing a key role in the enterohepatic recirculation of BAs [1]. Although ASBT is expressed in other organs, its functions there are largely unexplored. The Na-K-Cl cotransporter is a protein that aids in the secondary active transport of sodium, potassium, and chloride into cells. In humans there are two isoforms of this membrane transport protein, NKCC1 and NKCC2, encoded by two different genes. Two isoforms of the NKCC1/Slc12a2 gene result from keeping or skipping exon 21 in the final gene product.
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It is involved in the uptake of all types of bile acids from portal blood plasma, a process mediated by the co-transport of Na +.
After diffusion (bound by intracellular bile salt-binding proteins) to the canalicular membrane, monoanionic bile salts are secreted into bile canaliculi by the bile salt export pump Bsep (rodents) or BSEP (humans). The pre-S1 domain of the large HBsAg protein promotes attachment and entry of HBV into the hepatocyte via liver cell–specific receptor recently identified as Na (sodium) taurocholate cotransporting polypeptide (NTCP), which is an integral membrane protein used in bile acid transport. 23,24 There is evidence that hepatocyte entry may be a multistep process including binding to heparan sulfate proteoglycans, 25 which are found on a variety of cells, and clathrin-mediated endocytosis.
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1 ways to abbreviate Na(+)-bile Salt Co-transporter. How to abbreviate Na(+)-bile Salt Co-transporter? Get the most popular abbreviation for Na(+)-bile Salt Co-transporter updated in 2021
Injection of pig ileal poly (A)+ RNA into oocytes resulted in the functional expression of an Na(+)-gradient-stimulated taurocholate uptake within 2-5 days. The expressed Na(+)-dependent taurocholate uptake exhibited saturation kinetics (apparent Km 2021-04-01 bile acid moieties (GI and G2) are tethered together via a spacer, X, and where one of the two bile acid moieties carries a photoactivatable group.
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Intestinal sodium/glucose cotransporter 3 expression is epithelial and reflux disease: functionality of esophageal mucosa exposed to bile salt and trypsin in.
HCO3- kan nå cellen via en Na+/ HCO3 exchanger eller genom Fe2+ tas in i cellen genom cotransport med H+ (H+ gradient) Hemjärn Fe2+, tas Detta genom en ATP-beroende transportör, bile salt export pump, BSEP. 2. Gångarna i salivkörtlarna påverkas av hormon där Na+/K+ reabsorbtion sker via Aldosteron. Alltså kommer HCO3- ger alltså skydd mot saltsyran.
1991-12-01 · Burckhardt G, Kramer W, Kurz G, Wilson FA. Photoaffinity labeling studies of the rat renal sodium bile salt cotransport system. Biochem Biophys Res Commun. 1987 Mar 30; 143 (3):1018–1023. [Google Scholar] Wilson FA. Modern approaches to bile acid transport proteins. Hosp Pract (Off Ed) 1990 Apr 15; 25 (4):95–110. [Google Scholar]
While expression of NTCP is restricted to The SLC10 family of sodium/bile salt cotransporters contains over 50 members in animal, plant and bacterial species.
2000-04-01 · In addition to sodium/bile salt cotransport, sodium-independent bile salt transport pathways are also present at the basolateral plasma membranes of hepatocytes (8, 9, 11). These sodium-independent bile salt uptake systems have been less well characterized compared with the sodium-coupled uptake carrier, a fact that is reflected by the broad range of reported apparent K m values between 9 and However, both stomatin overexpression and knockdown increased NTCP-mediated taurocholate uptake while NTCP abundance at the plasma membrane was only increased in stomatin depleted cells.